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According to the World Health Organization, there are over 15 million people living with spinal cord injury. Spinal cord injury is often the result of trauma such as falls or car accidents [1]. Spinal cord injury involves partial or complete loss of sensory and/or motor function below the site of injury [3]. In addition to loss of motor function, patients suffering from spinal cord injury often deal with nociceptive or neuropathic pain, severely impairing their quality of life. NSAIDs (such as Ketoprofen, Ketorolac, Ibuprofen,and Diclofenac) are commonly used to manage pain and inflammation, but they may also play a role in neurological recovery following spinal cord injury. This is thought to occurthrough the inhibition of Rho-A and the shedding of L-selectin from innate immune cells, which may help modulate the injury response and promote healing.